PRRT2 and acute myeloid leukemia: Ludwig et al (1999) reported that CD73 expression was correlated with expression of protein kinase C (PKC) and epidermal growth factor receptor (EGFR). Protein kinase C is a known tumour metabolite in several proliferation-promoting pathways of EGF receptor signalling. Furthermore, Galmarini et al (2002) reported that CD73-positive acute myeloid leukaemia (AML) patients had worse disease-free survival and overall survival than negative patients, and suggested that CD73 expression might be a mechanism of resistance to cytarabine.