Cross talk between erb-1 and ER has been shown to activate the pathway, which has been associated with oestrogen-independent transcriptional activity (Aronica and Katzellenbogen, 1991; Pietras et al, 1995; Smith, 1998; Campbell et al, 2001), and breast cancer cell lines with activated Akt is resistant to the growth inhibitory effects of Tamoxifen (Degrafenried et al, 2002). Here, AKT1 is linked to breast carcinoma.