The aims of this study were to first update the survival data from previous studies of EGFR, MMP-9 and CA IX in a series of surgically resected NSCLC, assess if an association exists between EGFR and CA IX and develop a model using EGFR and related downstream factor expression to predict the outcome in NSCLC. The gene discussed is MMP9; the disease is non-small cell lung carcinoma.