In this study, we initially demonstrated that the expression of type I and type III collagens in pancreatic cancer tissues was at least three-fold higher than that in normal pancreatic tissue (Figure 1A), confirming previous reports (Gress et al, 1995; Imamura et al, 1995; Linder et al, 2001). Here, SGCG is linked to familial pancreatic carcinoma.