Interestingly, VHL-defective renal carcinoma cells demonstrate a variety of matrix-related abnormalities, including abnormal fibronectin assembly, defective formation of fibrillar adhesions, and changes in branching morphogenesis and migration (Ohh et al. 1998; Koochekpour et al. 1999; Davidowitz et al. 2001; Kamada et al. 2001; Esteban-Barragan et al. 2002). The gene discussed is VHL; the disease is renal carcinoma.