KMT2A and acute lymphoblastic leukemia: However, the difference between ALL and MLL did result in a significant decrease in AUC when compared with the difference between ALL and AML (85.98 vs 95.13%, P<0.0001), which also resulted in a considerable decrease in the level of the optimal balance between sensitivity and specificity (maximum of sensitivity+specificity=154.71 vs 175.82%), as could be expected.