Carriers of MSH6 mutations often display late age at onset, carcinomas of the endometrium, and low or no microsatellite instability (MSI) in tumours (Miyaki et al, 1997; Kolodner et al, 1999; Wijnen et al, 1999; Wu et al, 1999; Parc et al, 2000; Wagner et al, 2001; Berends et al, 2002; Peterlongo et al, 2003; Cederquist et al, 2004). This evidence concerns the gene MSH6 and neoplasm.