To address the question, which, if any, MSH6 missense mutations cause susceptibility to HNPCC, we previously studied the functionality of six MSH6 variants (S144I, G566R, P1087T, P1087R, R1095H, and L1354Q) (Kariola et al, 2002, 2003). The gene discussed is MSH6; the disease is hereditary nonpolyposis colon cancer.