IGFBP1 and hepatocellular carcinoma: Chronic exposure to nongenotoxic chemicals such as oxazepam and Wyeth-14,643 increased the expression of IGFBP-1 in a time-dependent manner (Iida et al. 2003), and overexpression of IGFBP-1 was also seen in transplacental arsenic-induced HCC and tumor-surrounding tissues (Liu et al. 2004).