Today, it is reported that the CTLA-4 (cytotoxic T-lymphocyte antigen-4) allele, localised on the chromosome 2p33, former IDDM12, is largely associated with the susceptibility of numerous common complex diseases, such as the common autoimmune disorders Graves' disease, the autoimmune hypothyroidism and type 1 diabetes [26]. This evidence concerns the gene CTLA4 and Autoimmunity.