LMNA and Emery-Dreifuss muscular dystrophy: Although this model fails to explain the cardiac conduction phenotype of EDMD, it is consistent with structural defects (aberrant shape and nuclear envelope herniations) seen in nuclei from EDMD patients (Fidzianska and Hausmanowa-Petrusewicz 2003) and in a subset of patients with other diseases linked to mutations in LMNA (“laminopathies”; Holaska et al. 2002; Östlund and Worman 2003).