To confirm the role of these two proteins in the prostate immunohistochemical studies on prostate cancer tissue microarrays were performed to identify IGFBP3 and RXR-alpha in both normal, nodular hyperplasia (benign prostatic hypertrophy), high grade prostatic intraepithelial neoplasia (HGPIN), invasive carcinoma, and metastatic prostatic carcinoma (table 2). The gene discussed is IGFBP3; the disease is Familial prostate cancer.