Glycosylphosphatidylinositol-anchored proteins have been recognised to modulate activity of intracellular tyrosine kinases (Stefanova et al, 1991; Brown, 1993; Skubitz et al, 1995) and our results indicate that c-Src, which plays a central role in pancreatic adenocarcinoma cellular invasion (Ito et al, 2003), may act as an effector of CEACAM6 signalling. Here, CEACAM6 is linked to pancreatic adenocarcinoma.