Moreover, the frequency of HLA-DRB1*04 was significantly greater in "high-scoring Celts." These authors concluded that the increased risk of cutaneous melanoma and other types of skin cancer in persons of Celtic ancestry in Wales is due not only to paler skin, but also to HLA-DRB1*04 and associated immunologic factors. The gene discussed is HLA-DRB1; the disease is cutaneous melanoma.