Our data that Apaf-1 reduction did not correlate with tumour thickness is in agreement with the findings by Fujimoto et al (2004), who showed that the pattern of Apaf-1 LOH did not correlate with tumour Breslow thickness, while Apaf-1 mRNA expression level was significantly lower in Apaf-1 LOH positive tumours. The gene discussed is APAF1; the disease is neoplasm.