BCL2 and melanoma: High expression of Bcl-2 antiapoptotic proteins, such as Bcl-2, Bcl-XL, and Mcl-1, may also contribute to melanoma progression and chemoresistance as antisense oligos against these genes can induce death of melanoma cells (Jansen et al, 1998; Heere-Ress et al, 2002; Thallinger et al, 2003).