We recently demonstrated that Sp-A, in breast carcinoma tissues, has a pattern of expression resembling that of its interaction partner [20]; thus, we hypothesize that co-ordinated induction of both SP-A and DMBT1 in breast tissue may be part of a protective response as suggested by Kang et al [30] for DMBT1 and Sp-D in pulmonary epithelium. The gene discussed is DMBT1; the disease is breast carcinoma.