Examples include, ras-effector nore1A (RASSF1A) [21,22], stratifin (14-3-3σ) [23], p15 and p16 [24], O6-methylguanine-DNA methyltransferase (MGMT) [25], mismatch repair gene (hMLH1) [26] and hyperplastic colon polyps gene (HPP1) [27]. The gene discussed is MLH1; the disease is polyp of colon.