RUNX1 and acute myeloid leukemia: The chromosomal translocation t(8;21) (q22;q22), which is associated with 10–15% of all cases of acute myeloid leukaemia, fuses the DNA binding domain of the transcription factor RUNX1 (also called AML1 or CBFα) to the almost complete open reading frame of CBFA2T1 (also named MTG8 or ETO) [1,2].