Interestingly, these also displayed hypermethylation in at least three of the genes APC, GSTP1, RARB2, and RASSF1A. Thus, the PCa specimens with ASC1 hypermethylation formed a precise subgroup of those with concomitant hypermethylation of these four genes (Figure 2C). The gene discussed is APC; the disease is posterior cortical atrophy.