Recently deregulation of the β-catenin and Wnt signalling pathway has been reported to induce cell proliferation when p14ARF function is lacking (Damalas et al, 2001), and a possible relation of dysfunction of β-catenin with UC-associated tumours has been reported (Walsh et al, 1999; Mikami et al, 2000; Aust et al, 2001; Haq et al, 2001). This evidence concerns the gene CDKN2A and neoplasm.