In order to assess whether ATM variants play a pathogenic role in prostate cancer development, we compared the frequencies of five ATM single-nucleotide polymorphisms (SNPs) 5557G>A, 5558A>T, 3161C>G, ivs38-8t>c, ivs38-15g>c in 618 British prostate cancer cases and 445 controls. This evidence concerns the gene ATM and Familial prostate cancer.