In vivo, CRP reflects Il-6 secretion (Klein et al, 1991) supported by high correlation between serum CRP and Il-6 concentrations in melanoma patients (Moshage et al, 1988; Castell et al, 1989; Kishimoto, 1989; Klein et al, 1991; Hirano, 1992; Tartour et al, 1996; Deichmann et al, 2000). The gene discussed is CRP; the disease is melanoma.