WNK2 and plasma cell myeloma: It would also be consistent with the observation that other inhibitors of the mevalonate pathway, such as statins, also induce comparable cell cycle changes (Vogt et al, 1997; Naderi et al, 1999).Very recently it was shown, for myeloma cells, that S-phase cell cycle arrest induced by nitrogen-containing bisphosphonates is linked to mitogen-activated protein kinase (MAPK) cascade activation (Iguchi et al, 2003).