To examine whether COX-2 expression is controlled through PPARγ activation in ovarian carcinoma cells, OVCAR-3 cells and the ovarian carcinoma cells established at our hospital were cultured in a semiconfluent state in normal culture medium or in media supplemented with 0.1–20 μM 15d-PGJ2, a PPARγ activator as described in Materials and Methods. The gene discussed is PTGS2; the disease is ovarian carcinoma.