PTGS2 and ovarian carcinoma: As shown in Figure 3, the present result showed that COX-2 was induced by TNF-α in ovarian carcinoma cells and that TNF-α-induced COX-2 expression was suppressed by 15d-PGJ2, suggesting that COX-2 expression was under the control of PPARγ and NFκB pathway in the ovarian carcinoma.