PTGS2 and central nervous system cancer: Zander et al (2002) described that activation of PPARγ transiently induced N-cadherin, the glioma differentiation marker, in human and rat glioma cells and in parallel, a subset of surviving cells showed de novo outgrowth of processes resembling astrocyte-like morphology based on PPARγ activation. Taking these results together including ours, activation of PPARγ and inhibition of COX-2 may be favourable for guiding neoplastic cells towards redifferentiation.