Inoue et al (2000) proposed that expression of COX-2 was regulated by a negative feedback loop mediated through PPARγ in macrophages. Badawi and Badr (2003) described that the altered expression of COX-2 and PPARγ might influence the development of human breast carcinoma and its progression to metastasis. Recently, PPARγ has been reported to be localised primarily to granulosa cells in ovarian tissue and to be involved in follicular development (Komar et al, 2001). The gene discussed is PTGS2; the disease is breast carcinoma.