WWOX and neoplasm: Furthermore, in agreement with our results and in contrast to those of Watanabe et al (2003), and supporting a putative tumour suppressor function for WWOX, loss of expression at RNA and protein level has been clearly demonstrated in breast, ovarian carcinoma cell lines and in various haematologic malignancies by several research groups (Bednarek et al, 2000; Paige et al, 2001; Ludes-Meyers et al, 2003; Ishii et al, 2003).