WWOX and neoplasm: WWOX (WW-domain containing oxidoreductase), a candidate tumour suppressor gene, spans over 1 Mb of DNA at 16q23.3–24.1, the location of FRA16D, the second most active FS in human genome (Glover et al, 1984; Bednarek et al, 2000, 2001; Ludes-Meyers et al, 2003).