In contrast, upregulated transcripts in tumor tissue and tumor cultures (Figure 1E, indicated by green vertical bar) included genes involved in epithelial differentiation (MAL, MAFB, RUNX1, KRT5), in the induction of apoptosis (DAPK1), and in tumor angiogenesis, and extravasation (SPARC) (Gene Ontology – GO annotations, ref [15]). This evidence concerns the gene SPARC and neoplasm.