Saltz et al (2001a) found no association between EGFR expression by immunohistochemistry in colorectal cancer and response to cetuximab. Similarly, no association was found between response to cetuximab and EGFR expression in SCCHN (Baselga et al, 2003), response to gefitinib in NSCLC (Bailey et al, 2003), and breast cancer (Iacobuzio-Donahue et al, 2003). The gene discussed is EGFR; the disease is non-small cell lung carcinoma.