Gastric cancer cells producing VEGF-C induce the proliferation and dilation of lymphatic vessels, resulting in the invasion of cancer cells into the lymphatic vessels and lymph node metastasis (Yonemura et al, 1999), and the lymphatic invasion was significantly increased in VEGF-C-positive early gastric carcinoma (Kabashima et al, 2001). This evidence concerns the gene VEGFC and cancer.