In fact, epigenetic inactivation of Calcitonin (11p15.1–15.2), p57 (11p15.5) and Myf-3 (11p15.4) genes are frequently observed in both childhood and adult ALL (Roman-Gomez et al, 2001; Garcia-Manero et al, 2002; Li et al, 2002). This evidence concerns the gene CALCA and acute lymphoblastic leukemia.