There was a significant concordance between Dkk-3 methylation and the presence of Calcitonin methylation; methylation was present in 30 out of 42 (71.4%) Calcitonin-methylated tumours vs 13 out of 63 (20.6%) Calcitonin nonmethylated tumours (P=0.0001). This evidence concerns the gene CALCA and neoplasm.