Furthermore, because bFGF is produced by OSPC and can bind to FGF receptor 2 expressed on these tumours (Steinfeld et al, 1996), it is likely that the combined overexpression of glypicans and FGF receptor 2 genes found in OSPC may represent a common molecular abnormality with important functional consequences for the progression of OSPC. The gene discussed is GPC1; the disease is neoplasm.