Although Geminin is a potential inhibitor of cell proliferation (McGarry and Kirschner, 1998; Wohlschlegel et al, 2000), a regulator of differentiation (Kroll et al, 1998), and may be required for maintenance of genomic integrity (Saxena and Dutta, 2003), its role in tumour progression remains to be determined. Here, GMNN is linked to neoplasm.