EEF1D and melanoma: Sinha et al (2000) indicated that human EF-1 delta was overexpressed in melanoma cell lines exhibiting chemoresistance towards antineoplastic drugs, such as vindesine, cisplatin, fotemstine and etoposide. They suggested that the development of chemoresistance towards anti-neoplastic drugs in melanoma cell lines could be the results of a changed functionality of the general translation machinery. With regard to ionising radiation, Jung et al (1994) indicated that EF-1 delta was a radiation-inducible gene and might participate in the G2-M cell cycle checkpoint.