Gene array technology has recently identified prostasin (a serine protease, previously identified in prostatic secretions), osteopontin (a secreted bone morphogen) and creatine kinase B (a marker for renal and lung cancers) to be elevated in serum from patients with ovarian cancer (Mok et al, 2001; Kim et al, 2002). Here, PRSS8 is linked to ovarian cancer.