CCND1 and colorectal carcinoma: Our observational data showing that there is no simple relationship between NSAID-induced changes in cyclin D1 protein levels and CRT (measured by TOPflash activity), despite reduction in nuclear β-catenin content, is consistent with the concept that reduced cyclin D1 expression and inhibition of cell proliferation of human CRC cells occurs via a mechanism that is not simply explained by decreased CRT, subsequent to reduced β-catenin levels.