Dihlmann and colleagues have reported that indomethacin and aspirin reduced CRT (measured using synthetic TCF-reporter genes, which included either a minimal c-FOS or SV40 promoter), as well as cyclin D1 mRNA and protein levels, in SW948 human CRC cells (Dihlmann et al, 2001). This evidence concerns the gene CCND1 and colorectal carcinoma.