Levels of cyclin D1 protein in SW480 human CRC cells after therapy with different concentrations of diclofenac and sulindac sulphide for 48 h did mirror TOPflash activity but not for indomethacin or sulindac sulphone, which were variably associated with unchanged or increased TOPflash activity despite decreased cyclin D1 protein levels (compare Figures 3 and 5). The gene discussed is CCND1; the disease is colorectal carcinoma.