Although the effects of the NSAIDs used in this study on proliferation and apoptosis of SW480 human CRC cells have been previously described (Hixson et al, 1994; Piazza et al, 1997b; Smith et al, 2000; Yamazaki et al, 2002), there has been no previous study of the effects of a series of NSAIDs on expression of β-catenin and the cell cycle regulatory protein cyclin D1 by these cells. The gene discussed is CCND1; the disease is colorectal carcinoma.