Dihlmann and colleagues have reported that indomethacin and aspirin reduced CRT (measured using synthetic TCF-reporter genes, which included either a minimal c-FOS or SV40 promoter), as well as cyclin D1 mRNA and protein levels, in SW948 human CRC cells (Dihlmann et al, 2001). The gene discussed is HNF4A; the disease is colorectal carcinoma.