Finally, increased expression of GD1b and GT1b in rat pheochromocytoma cells transfected with GD3 synthase occurs in parallel with trk-A dimerisation (Fukumoto et al, 2000), which in turn is associated with improved prognosis in NB (Nakagawara et al, 1993). The gene discussed is NTRK1; the disease is hereditary pheochromocytoma-paraganglioma.