To further examine the role of Bcl2 in preventing the potentiating effect of chemotherapy and ionising radiation to AdTRAIL-induced apoptosis, we studied the cleavage of procaspase-8 and Bid in H460 and H460Bcl2 cells after infection with AdTRAIL (MOI 10) alone or in combination with 15 nM DOX or PTX, 15 μM CDDP or 6 Gy irradiation 3 days postinfection. This evidence concerns the gene BCL2 and infection.