TNFSF10 and non-small cell lung carcinoma: This observation is in line with a previous report by Sun et al (2001), who showed that Bcl2 overexpression inhibits soluble TRAIL-induced apoptosis in NSCLC cells; however, instead of their suggestion that Bcl2 acts by preventing caspase-7 activation, we find that Bcl2 suppresses procaspase-8 cleavage that as mentioned above we have found to occur in a mitochondria-controlled manner in NSCLC cells (Ferreira et al, 2000).