On the other hand, type-II cells, including several colon carcinoma, neuroblastoma and NSCLC cell lines, are characterized by a strong involvement of the mitochondrial pathway via the caspase-8-dependent activation of the proapoptotic Bcl2 family member Bid, also known as the amplification loop (Sun et al, 2001; Fulda et al, 2002; Ozoren and El-Deiry, 2002). This evidence concerns the gene CASP8 and non-small cell lung carcinoma.