In addition, many macrophages produced factors, proteases and protease activators such as transforming growth factor-β (TGFβ), platelet-derived growth factor, interleukin-6 (IL-6), urokinase plasminogen activator and Tissue-type Plasminogen Activator (t-PA) that may cause degradation of extracellular matrix to facilitate the tumour cell invasion and migration and induce angiogenesis (Egami et al, 2003; Eubank et al, 2003; Hildenbrand et al, 1995; Klimetzek and Sorg, 1977). The gene discussed is IL6; the disease is neoplasm.