MSH2 and hereditary nonpolyposis colon cancer: Estimated costs have ranged between €450 [£334*] and $1000 [£688] (Vasen et al, 1998) [£834*] (Brown and Kessler, 1995, 1996) for examining the hMLH1 and hMSH2 genes for HNPCC mutations (Debniak et al, 2000).