This result leads to two conclusions: (i) the autocrine signalling pathway of NO previously observed in normal human tubular epithelial cells (Jarry et al, 2003) is maintained in benign tumours and low malignant potential RCC but not in high-grade clear cell RCC, and (ii) the persistence of sGC expression in all tumour types implies that tumour cells remain sensitive to the bioregulatory roles of exogeneous NO. The gene discussed is SGCB; the disease is neoplasm.