The data presented here indicate that in H 209 SCLC cells, blockade of IGF-1R signalling synergistically enhances the antiproliferative effects of an anti-c-kit strategy, and that while both anti-IGF-1R and anti-c-kit strategies as single agents can induce apoptosis in this system, combination treatment results in synergy of apoptotic induction. This evidence concerns the gene IGF1R and small cell lung carcinoma.