In contrast, the synergy in growth reduction was observed to parallel a synergy in apoptosis induction (IC75 CI=0.62 at AG 1024 2.5 μM and AG 1296 5.0 μM, Figure 2B), pointing to a cytotoxic effect in these cancer cells associated with the co-targeting of IGF-1R and c-kit. This evidence concerns the gene KIT and cancer.