Owing to its role in cytoskeletal reorganisation, in focal adhesion contacts (Nobes and Hall, 1995; Kimura et al, 1996; Leung et al, 1996) and in tumour invasion (Clark et al, 2000), RhoC was chosen from the pool of 668 differentially expressed genes for further analysis of the possibility that increased RhoC expression might correlate with HCC metastasis. Here, RHOC is linked to hepatocellular carcinoma.