In small cell lung carcinoma, a tumour that displays a downregulation of HLA class I antigen and shares neuroectodermal origin with NB, IFN-γ transfection have been demonstrated to enhance HLA class I surface expression and restore presentation of a MAGE-3 peptide to CTL (Traversari et al, 1997). The gene discussed is IFNG; the disease is neuroblastoma.