Among the cytokines so far investigated, interferon (IFN)-γ appears to be of particular interest due to its ability to upregulate surface expression of HLA class I molecules in human NB cells (Lampson et al, 1983; Ponzoni et al, 1993; Corrias et al, 2001) and to activate cytotoxic T-lymphocyte-mediated antitumour responses in a murine model (Watanabe et al, 1989). Here, IFNG is linked to neuroblastoma.