This approach appears feasible also for human NB cells since NB tumours express CTL-defined TAA, such as tyrosine hydroxylase ((Lode et al, 2000), MAGE-1 and 3 (Rimoldi et al, 1993; Corrias et al, 1996), NY-ESO (Soling et al, 1999; Rodolfo et al, 2003) and ALK (Lamant et al, 2000), and tumour-specific cytolytic T lymphocytes have been isolated from NB-bearing patients (Rosenthal et al, 1994; Bowman et al, 1998; Sarkar et al, 2001; Rousseau et al, 2003). The gene discussed is TH; the disease is neuroblastoma.