RPS19 and Blackfan-Diamond anemia: In humans, there is a possible association of mutations in one particular RP gene with cancer: approximately 25% of both sporadic and familial cases of Diamond-Blackfan anemia (DBA) are associated with a mutation of rpS19 (Draptchinskaia et al. 1999), and this syndrome includes an increased risk of developing leukemia (Wasser et al. 1978).