Combining the two ‘candidate’ SNPs (P187S and R72P) revealed an increased risk for breast cancer of double heterozygotes (P187S/R72P) of the NQO1 and TP53 genes (OR=1.88; 95% CI 1.13–3.15; P=0.011), suggesting a possible interaction of these two loci. This evidence concerns the gene TP53 and breast cancer.