In a prospectively planned analysis of patients with ER-positive and/or PgR-positive tumours (78.9% of fulvestrant-treated patients and 77.4% of tamoxifen-treated patients), in the population intended for treatment with endocrine therapy, the TTP was similar between the two treatments (median TTP: 8.2 vs 8.3 months for fulvestrant and tamoxifen, respectively; HR: 1.10; 95% CI, 0.89–1.36; P=0.39). The gene discussed is PGR; the disease is neoplasm.