Preincubation of MM cells with the caspase-8 inhibitor Z-IETD-FMK inhibited the synergistic effect of TRAIL and α-TOS, while treatment with the pan-caspase inhibitor Z-VAD-FMK completely inhibited apoptosis initiated by the two inducers alone or in combination. Here, TNFSF10 is linked to Miyoshi myopathy.