MYC and neoplasm: Studies of neoplasms of the colon, testis, ovary and liver have shown that predominantly nuclear localisation of c-Myc tends to occur in benign lesions, while cytoplasmic localisation tends to occur in more malignant tumours (Sikora et al, 1985; Sundaresan et al, 1987; Melhem et al, 1992; Sasano et al, 1992; Yuen et al, 2001).