ERBB2 and breast carcinoma: Unlike some oncogenes, such as N-myc, which typically demonstrates gene amplification copy numbers of greater then 10 in neuroblastoma, and HER-2/neu (Sartelet et al, 2002), whose copy numbers range up to 14–40 in breast carcinomas (Isola et al, 1999), gene copy numbers of c-myc are not as greatly increased.