RB1 and neoplasm: Our collection consisted of tumour suppressors such as HPC1, APC, unknown TSG on 8p22, TP53, TFF1, TFF2, cell cycle controlling (RB1, CDKN2A) and mismatch repair genes (MLH1, MSH2), as well as ‘metastasis’ genes NME1, NME2 and NME3 (Scholnick et al, 1996; Gallo et al, 1997; Seifert et al, 1997; Matsuura et al, 1998; Ransom et al, 1998; Grati et al, 2000; Oba et al, 2001; Carvalho et al, 2002; Tsuda et al, 2002).