We herein report finding of two such types of EGFR-derived peptides at position 479–488 and 1138–1147, both of which were recognised by the majority of patients' sera (IgG), and also possessed the ability to induce HLA-A2-restricted peptide-specific CTLs against EGFR-positive tumour cells in peripheral blood mononuclear cells (PBMCs) of epithelial cancer patients. Here, EGFR is linked to neoplasm.