An inverse correlation between E-cad and Snail has been reported in a panel of epithelial and dedifferentiated cells derived from carcinomas in various etiologies, including oral squamous carcinoma, cancers of the breast, pancreas, colon, and bladder, melanoma, and HCC (Batlle et al, 2000; Cano et al, 2000; Cheng et al, 2001; Yokoyama et al, 2001; Blanco et al, 2002; Jiao et al, 2002). The gene discussed is SNAI1; the disease is melanoma.