In this experiment, we have focused on another mechanism of E-cad repression by zinc finger transcription factors Snail and SIP1 in HCC cell lines, since Snail and SIP1 have been described to not only repress E-cad expression, but also contribute to cellular dedifferentiation and cancer invasion (Batlle et al, 2000; Cano et al, 2000; Comijn et al, 2001; Yokoyama et al, 2001). This evidence concerns the gene ZEB2 and hepatocellular carcinoma.