Id-1 overexpression has been found in several types of primary human cancers including breast, pancreatic, prostate, melanoma and cervical cancers (Maruyama et al, 1999; Langlands et al, 2000; Lin et al, 2000; Polsky et al, 2001; Schindl et al, 2001; Ouyang et al, 2002a; Wang et al, 2002; Schindl et al, 2003; Schoppmann et al, 2003). This evidence concerns the gene ID1 and melanoma.